• Acta endocrinologica · Oct 1985

    The effect of naloxone on ATCH and beta-endorphin in patients with Cushing's disease.

    • B Baranowska, W Dorobek, W Misiorowski, W Jeske, and M H Abdel-Fattah.
    • Acta Endocrinol. 1985 Oct 1; 110 (2): 170-5.

    AbstractEndogenous opiates may be important in the control of ACTH secretion in men. The effect of opiate receptor blockade by naloxone on ACTH, beta-endorphin-like substance and cortisol release was studied in healthy women and in 9 patients with Cushing's disease. In the healthy subjects, ACTH, beta-endorphin and cortisol levels were increased in response to naloxone. However, in 3 our of the 9 patients with Cushing's disease, a paradoxical decrease in serum ACTH, cortisol and beta-endorphin concentrations was observed after naloxone administration. In the patients with a paradoxical response to naloxone, transsphenoidal microadenomectomy was ineffective.

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