• J Affect Disord · Apr 2019

    The associations between subjective and objective cognitive functioning across manic or hypomanic, depressed, and euthymic states in Chinese bipolar patients.

    • Xiaoling Lin, Dali Lu, Zhixin Huang, Wen Chen, Xia Luo, and Yinghua Zhu.
    • School of Nursing, Sun Yat-sen University, Guangzhou 510078, China. Electronic address: linxling3@mail.sysu.edu.cn.
    • J Affect Disord. 2019 Apr 15; 249: 73-81.

    BackgroundPatients may present cognitive deficits during all stages of bipolar disorder (BD). Few studies have examined self-reported cognitive difficulties and its relation to neurocognitive dysfunction during symptomatic periods of BD. This study aimed to compare subjective cognitive functioning and explore associations between subjective and objective cognitive functioning across different BD clinical states, and investigate the predicting and moderating roles of mood symptoms.MethodsSubjective cognitive functioning (measured by Cognitive Complaints in Bipolar Disorder Rating Assessment, COBRA) and several domains of cognitive functioning (assessed by a neuropsychological battery), including executive functions, attention and processing speed, and visual memory, were examined in 48 hypomanic or manic patients, 42 depressed bipolar patients, 50 euthymic bipolar patients and 60 healthy comparisons.ResultsAll patients exhibited subjective and objective cognitive deficits in relation to healthy comparisons. There was a significant association between subjective and objective cognitive functioning in euthymic group, but the association was not significant in acute symptomatic groups, which could be moderated by depressive or manic symptoms in depressive or manic group, respectively. Subjective cognitive functioning was significantly correlated with mood symptoms, and the best predictor of subjective cognitive functioning was depressive symptoms.LimitationsThis was a cross-sectional study with a mixed sample of inpatients and outpatients. The medication effect was not adjusted.ConclusionsThe associations between subjective and objective cognitive dysfunction varied in clinical states, and mood symptoms moderated the associations. A neuropsychological test battery is required to substantiate actual cognitive dysfunction in clinical settings, irrespective of subjective cognitive deficits.Copyright © 2019. Published by Elsevier B.V.

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