• Rogério Nogueira Soares, Raylene A Reimer, and Juan Manuel Murias.
• Faculty of Kinesiology, University of Calgary, 2500 University Dr. NW, Calgary, AB T2N 1N4, Canada; Coordination for the Improvement of Higher Education Personnel (CAPES), Setor Bancario Norte, Quadra 2 Bloco L, Brasilia, DF 70.040-031, Brazil. Electronic address: rogerio.soares@ucalgary.ca.
• Microvasc. Res. 2017 May 1; 111: 67-71.

BackgroundPostprandial hyperglycemia is associated with impaired vascular responsiveness. Recent studies have established the use of a near-infrared spectroscopy (NIRS)-derived approach, combined with a vascular occlusion test (VOT), to examine vascular responsiveness within the microvasculature in normoglycemia. The aim of this study was to examine whether this NIRS-VOT technique could detect differences in vascular responsiveness following a hyperglycemic challenge.Methods And ResultsFourteen young healthy individuals participated in the study. Participants underwent five vascular occlusion tests (pre, 30, 60, 90 and 120min after glucose ingestion). Vascular responsiveness was determined by the slope 2 of oxygen saturation (Slope 2 StO2) and the area under the curve of oxygen saturation (StO2AUC) signal. All individuals had a significant increase in blood glucose concentration after 30min (p<0.001), 60min (p<0.001) and 90min (p<0.01) after glucose ingestion. The Slope 2 StO2 increased at 90min (p<0.01) after glucose ingestion. Conversely, The StO2AUC was significantly decreased 90min following the glucose challenge (p<0.01). A negative correlation was observed between average StO2AUC and average Slope 2 StO2 (r=-0.995; p<0.05).ConclusionThis study showed that the NIRS-VOT technique is capable of detecting differential changes in vascular responsiveness to a hyperglycemic challenge, as indicated by a steeper Slope 2 StO2 and decreased StO2AUC following 90min of an oral glucose challenge.Copyright © 2017 Elsevier Inc. All rights reserved.

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