• Rogério Nogueira Soares and Juan M Murias.
• Faculty of Kinesiology, University of Calgary, 2500 University Dr. NW, Calgary, AB T2N 1N4, Canada.
• Microvasc. Res. 2018 Jul 1; 118: 31-35.

BackgroundMicrovascular dysfunction is an early complication in obesity-related cardiovascular disease (CVD) that can lead to changes in hemodynamic function and endothelial cell expression throughout the vasculature that is vessel specific. This study aimed to evaluate whether the near-infrared spectroscopy (NIRS) combined with a vascular occlusion (VOT) assessment was capable of detecting differences in vascular responsiveness within the microvasculature of the lower limb between lean and obese individuals.Methods And ResultsTwenty lean (BMI = 21.6 ± 1.3) and 17 obese individuals (BMI = 33.9 ± 1.1) participated in the study. Individuals underwent a VOT (5 min of baseline, 5 min of occlusion, and 8 min following cuff release) and vascular responsiveness was evaluated by the Slope 2 (Slope 2 StO2) and the area under the curve (StO2AUC) of oxygen saturation (StO2) signal during reperfusion. The difference between the minimal and the maximal value of StO2 was calculated as the Amplitude of the StO2 response. The Slope 2 StO2 of the obese individuals was smaller (0.68 ± 0.07%·s-1) than the Slope 2 StO2 of the lean individuals (1.08 ± 0.13%·s-1;P < 0.05). The StO2AUC of the obese was smaller (978 ± 169%·s-1) than the StO2AUC of the lean individuals (1708 ± 168%·s-1; P < 0.001). The amplitude of StO2 was smaller in obese individuals than the lean ones (30.4 ± 2.9 vs 21.6 ± 1.3 StO2 (%), respectively; P < 0.05). There was a significant correlation between Slope 2 StO2 and StO2AUC for lean individuals (r = 0.745; P < 0.001).ConclusionThis study demonstrated differences in vascular responses within the microvasculature of the lower limb between lean and obese individuals.Copyright © 2018 Elsevier Inc. All rights reserved.

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