• Curr Treat Option Ne · Mar 2009

    Decompressive hemicraniectomy for malignant hemispheric infarction.

    • Katayoun Vahedi.
    • Katayoun Vahedi, MD Neurology Department and Stroke Unit, Lariboisiére Hospital, Assistance Publique Hôpitaux de Paris, 2 Rue Ambroise Paré, 75010 Paris, France. katayoun.vahedi@lrb.aphp.fr.
    • Curr Treat Option Ne. 2009 Mar 1; 11 (2): 113-9.

    AbstractMalignant middle cerebral artery infarction is associated with up to 80% mortality due to ischemic edema and brain herniation. No medical therapy has proven its efficacy in efficiently and durably reducing brain edema and improving patients' outcome. Decompressive surgery by a large hemicraniectomy with durotomy has been suggested as a life-saving emergency procedure. However, because of the lack of established prognostic criteria, the fear of severe and "unacceptable" residual disability in surviving patients, and the impossibility of considering the opinion of the patient at the time of decision, there was no consensus regarding this surgery. Recently the results of a pooled analysis of three European randomized trials (DECIMAL, DESTINY, and HAMLET) of early (

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