• Shu-ben Li, Jian-xing He, Shi-yue Li, Han-zhang Chen, Wei-qiang Yin, Xiang-yang Cheng, Jun Liu, and Yu Chen.
• The First Affiliated Hospital of Guangzhou Medical College, Guangzhou Institute of Respiratory Disease, Guangzhou 510120, China.
• Zhonghua Zhong Liu Za Zhi. 2012 Aug 1; 34 (8): 613-5.

ObjectiveTo evaluate the clinical value of endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) biopsy for diagnosis of PET-CT positive mediastinal lymph nodes.MethodsOne hundred and twenty-six patients with lung cancer undergoing both PET-CT scanning and EBUS-TBNA biopsy in the First Affiliated Hospital of Guanzhou Medical College from July 2008 to August 2010 were included in this study. There were 89 male and 37 female patients with a mean age of 56.3 years (range 34 to 81 years). (18)FDG-PET was considered positive in mediastinal nodes if the PET-CT reported hypermetabolic activity consistent with malignant disease (standardized uptake value > 2.5). All of the patients were clinically followed up.ResultsAmong the 126 patients, 185 stations of lymph nodes were punctured. The mean diameter of the nodes was 13.6 mm and the range was 6 - 23 mm. There were no procedural complications. The diagnostic accuracy, sensitivity, and specificity of EBUS-TBNA were 95.7%, 95.7%, and 100%, respectively.ConclusionsEBUS-TBNA is a minimally invasive, highly effective and accurate, practical and safe procedure for diagnosis of PET-CT positive mediastinal lymph nodes.

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