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Randomized Controlled Trial
Meaningful relief with flurbiprofen 8.75 mg spray in patients with sore throat due to upper respiratory tract infection.
- Ferdinandus de Looze, Marc Russo, Mark Bloch, Barney Montgomery, Adrian Shephard, and Robert DeVito.
- AusTrials Pty Ltd, Sherwood, QLD, Australia.
- Pain Manag. 2018 Mar 1; 8 (2): 79-83.
AimEvaluate the efficacy of flurbiprofen 8.75 mg spray for sore throat relief.Patients & MethodsRandomized, double-blind study in adults with sore throat due to upper respiratory tract infection who took flurbiprofen (n = 249) or placebo spray (n = 256). Pain relief was assessed using the Sore Throat Relief Rating Scale.ResultsFlurbiprofen spray provided significantly greater relief versus placebo from 20 min to 6 h (p < 0.0001; maximum difference: 75 min). Sore throat severity was reduced ≥-2.2 on the Sore Throat Scale from 75 min to 6 h, indicating meaningful relief. Significantly more patients taking flurbiprofen spray reported ≥30 min of 'at least moderate' relief versus placebo over 6 h (p < 0.0001). Most adverse events were mild.ConclusionFlurbiprofen spray provides rapid, long-lasting and clinically meaningful relief from sore throat (ANZCTR: ACTRN12612000457842).
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