• Primary care · Dec 2020

    Review

    Autosomal Dominant Polycystic Kidney Disease.

    • Parvathi Perumareddi and Darin P Trelka.
    • Florida Atlantic University, Schmidt College of Medicine, 777 Glades Road, Boca Raton, FL 33431, USA. Electronic address: pperumar@health.fau.edu.
    • Prim. Care. 2020 Dec 1; 47 (4): 673-689.

    AbstractAutosomal Dominant Polycystic Kidney Disease is an inherited multisystemic disorder of the renal tubules with subsequent formation of multiple cysts and enlargement of the kidney, affecting various organs. Diagnosis is initially suspected in those with family history and/or individuals who develop hypertension early on (secondary hypertension) or certain symptoms. Renal function is initially preserved for years secondary to compensatory mechanisms. Associated conditions include: liver cysts, berry aneurysms, kidney stones, etc. The disease course is variable, but patients often progress to end-stage renal failure by age 60. There is no known cure, however, risk factor modification at early stages is critical. Renal transplant is the optimal treatment in ESRD.Copyright © 2020 Elsevier Inc. All rights reserved.

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