• Sangbin Han, Jaesik Park, Sang Hyun Hong, Soojin Lim, Yong Hyun Park, and Min Suk Chae.
• Department of Emergency medicine, Cheongyang Health Center County Hospital, Chungcheongnam-do, Republic of Korea.
• BMC Anesthesiol. 2020 Oct 28; 20 (1): 273.

BackgroundEnhancing postoperative recovery of the donor is important to encourage living kidney donation. We investigated the effects of anesthetic agents (intravenous [IV] propofol versus inhaled [IH] sevoflurane) on the quality of early recovery of healthy living kidney donors after hand-assisted laparoscopic nephrectomy (HALN) under analgesic intrathecal morphine injection.MethodsThis single-center, prospective randomized controlled study enrolled 80 living donors undergoing HALN from October 2019 to June 2020 at Seoul St. Mary's Hospital. Donors were randomly assigned to the IV propofol group or IH sevoflurane group. To measure the quality of recovery, we used the Korean version of the Quality of Recovery-40 questionnaire (QoR-40 K) on postoperative day (POD) 1, and ambulation (success rate, number of footsteps) 6-12 h after surgery and on POD 1. The pain score for the wound site, IV opioid requirement, postoperative complications including incidences of nausea/vomiting, and length of in-hospital stay were also assessed.ResultsThe global QoR-40 K score and all subscale scores (physical comfort, emotional state, physical independence, psychological support, and pain) were significantly higher in the IV propofol group than in the IH sevoflurane group. The numbers of footsteps at all time points were also higher in the IV propofol group. Donors in the IV propofol group had a lower incidence of nausea/vomiting, and a shorter hospitalization period.ConclusionsTotal IV anesthesia with propofol led to better early postoperative recovery than that associated with IH sevoflurane.Trial RegistrationClinical Research Information Service, Republic of Korea (approval number: KCT0004351 ) on October 18, 2019.

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