• Internal medicine · Jan 2020

    Case Reports

    Acute Interstitial Nephritis and Acute Tubular Injury Due to a Transdermal Loxoprofen Patch.

    • Takahiro Shinzato, Ken Ohara, Hiroaki Kaminaga, Taro Sugase, Takahiro Masuda, Daisuke Nagata, Katano Saki, Yoshitaka Kinoshita, Taro Kubo, Toshihiro Shimizu, Koji Nanmoku, and Takashi Yagisawa.
    • Department of Renal Surgery and Transplantation, Jichi Medical University Hospital, Japan.
    • Intern. Med. 2020 Jan 1; 59 (21): 2733-2736.

    AbstractA transdermal patch formulation of a non-steroidal anti-inflammatory drug (NSAID) used by a 44-year-old man resulted in acute interstitial nephritis and acute tubular injury. This patient also had a history of mild kidney dysfunction and osteoporosis. The NSAID patch had been prescribed after a traffic accident. He was also receiving a vitamin D analog and taking over-the-counter calcium supplements. Two months later, renal dysfunction and hypercalcemia were discovered. A renal biopsy showed acute interstitial nephritis and acute tubular injury. Once these agents were withdrawn, the renal function recovered. This is the first reported occurrence of biopsy-proven acute interstitial nephritis attributable to NSAID patch usage.

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