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Internal medicine journal · Jan 2020
Case ReportsWilson disease: copper deficiency and iatrogenic neurological complications with zinc therapy.
- Landy M Wu, Adel Ekladious, Luke Wheeler, and Abdulrazak A Mohamad.
- Department of Medicine, Frankston Hospital, Melbourne, Victoria, Australia.
- Intern Med J. 2020 Jan 1; 50 (1): 121-123.
AbstractA 17-year-old female was diagnosed with Wilson disease and commenced on oral zinc therapy. She re-presented 6 months later with a fall and had classical signs of subacute combined degeneration of the spinal cord confirmed on nerve conduction studies, as a result of zinc-induced copper deficiency. After 6 months of copper therapy, she made a complete recovery with no residual neurological deficits. Early detection of zinc-induced copper deficiency and stringent follow-up mechanisms are crucial. Early initiation of copper replacement may both limit and completely reverse neurological deficits.© 2020 Royal Australasian College of Physicians.
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