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Internal medicine journal · Jan 2020
Case ReportsDoes glyceryl trinitrate cause central sympatholytic effects? Insights from a case of baroreflex failure.
- Sarah Tan, Lin Xie, Robert Anderson, Andrew Hammond, Angelina Y Fong, Seok Lim, Andrew M Allen, and Stephen B Harrap.
- Department of General Medicine, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
- Intern Med J. 2020 Jan 1; 50 (1): 114-117.
AbstractWhether part of the blood pressure lowering effects of glyceryl trinitrate (GTN) is the result of centrally mediated reduction in sympathetic activity is debated. In humans, baroreflex activity potentially obscures the central sympatholytic effects of GTN. We examined this in a routine clinical tilt test in a patient with baroreflex failure secondary to previous neck radiotherapy. With reduced baroreflex function we observed an exaggerated fall in blood pressure and reduced sympathetic activity with GTN, supporting a peripheral vasodilation and central sympatholytic effect.© 2020 Royal Australasian College of Physicians.
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