• Headache · Sep 2002

    Case Reports

    SUNCT syndrome responsive to lamotrigine.

    • Jose M Gutierrez-Garcia.
    • Department of Neurology, University Hospital, Valladolid, Spain.
    • Headache. 2002 Sep 1; 42 (8): 823-5.

    BackgroundShort-lasting, unilateral, neuralgiform headache attacks with conjunctival injection, tearing, rhinorrhea (SUNCT syndrome) is a headache form generally refractory to drug therapy. Occasional patients with SUNCT have been reported with a successful response to lamotrigine.ObjectiveTo report two patients with SUNCT treated with lamotrigine.MethodsClinical history, neurologic examination, and brain magnetic resonance imaging.ResultsBoth patients with SUNCT syndrome were successfully treated with lamotrigine. In both cases, when lamotrigine was tapered off, the attacks reappeared, only to disappear when the dose was again increased. In addition, lamotrigine was well tolerated and no undesired side-effects were reported.ConclusionIf the positive effect of lamotrigine in patients with SUNCT is confirmed in other cases, lamotrigine could become the first specific treatment for SUNCT syndrome.

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