• Yoon Seok Jung, Hyuk-Hoon Kim, Hee Won Yang, and Sangchun Choi.
• Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Republic of Korea.
• Medicine (Baltimore). 2020 Nov 6; 99 (45): e23159.

RationaleUnprecedented heatwaves over the past several years are getting worse with longer duration in the course of global warming. Heatstroke is a medical emergency with multiple organ involvement and life-threatening illness with a high mortality rate of up to 71%. Uncontrolled damage to the central nervous system can result in severe cerebral edema, permanent neurological sequelae, and death. However, regarding the therapeutic aspects of heat stroke, there was no therapeutic strategy after the rapid cooling of the core body temperature to <39°C to prevent further injury.Patient ConcernsEach of 3 patients developed a change of mental statuses after the exposure to summer heatwaves or relatively high environmental temperatures with high humidity in the sauna.DiagnosesThe patients were diagnosed with severe heatstroke since they showed cerebral edema and multiple organ dysfunction based on the results from laboratory tests and the findings in brain computed tomography scan.InterventionsThe patients underwent induced therapeutic hypothermia (<36°C) between 24 and 36 hours in the management of severe heatstroke.OutcomesThe patients survived from cerebral edema and multiple organ dysfunction.LessonsWe believe that targeted temperature management (<36°C) will help treat severe heatstroke. Thus it should be considered for reducing the chance of development of complications in multiple organs, especially in the central nervous system, when managing patients with severe heatstroke.

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