• Rev Cardiovasc Med · Jan 2011

    Case Reports

    Takotsubo cardiomyopathy due to iatrogenic methadone withdrawal.

    • Faisal B Saiful, James Lafferty, Chin Hee Jun, Sumaya Teli, Srinivas Duvvuri, Saakshi Khattri, and Tariq Bhat.
    • Department of Medicine, Staten Island University Hospital, Staten Island, NY, USA.
    • Rev Cardiovasc Med. 2011 Jan 1; 12 (3): 164-7.

    AbstractTakotsubo cardiomyopathy is a syndrome characterized by transient apical ballooning or reversible midventricular systolic dysfunction. Most cases occur in postmenopausal women and are typically triggered by an acute medical illness or emotional or physical stress. Its presentation is highly suggestive of myocardial ischemia, but there is little or no evidence of epicardial coronary artery disease. To our knowledge there are only three reported cases in the literature of Takotsubo cardiomyopathy induced by opioid agonist withdrawal in adults; ours is the first reported case of iatrogenic methadone withdrawal leading to Takotsubo cardiomyopathy.

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