• Ayman El Nakeeb, Mohamed El Hemaly, Waleed Askr, Mohamed Abd Ellatif, Hosam Hamed, Ahmed Elghawalby, Mohamed Attia, Tallat Abdallah, and Mohamed Abd ElWahab.
• Gastroenterology Surgical Center, Mansoura University, Mansoura, Egypt. Electronic address: elnakeebayman@yahoo.com.
• Int J Surg. 2015 Apr 1; 16 (Pt A): 1-6.

BackgroundThe ideal technical pancreatic reconstruction following pancreaticoduodenectomy (PD) is still debated. The aim of the study was to assess the surgical outcomes of duct to mucosa pancreaticojejunostomy (PJ) (G1) and invagination PJ (G2) after PD.MethodsConsecutive patients treated by PD at our center were randomized into either group. The primary outcome measure was the rate of postoperative pancreatic fistula (POPF); secondary outcomes included; operative time, day to resume oral feeding, postoperative morbidity and mortality, exocrine and endocrine pancreatic functions.ResultsOne hundred and seven patients treated by PD were randomized. The median operative time for reconstruction was significantly longer in G1 (34 vs. 30 min, P=0.002). POPF developed in 11/53 patients in G1 and 8/54 patients in G 2, P=0.46 (6 vs. 2 patients had a POPF type B or C, P=0.4). Steatorrhea after one year was 21/50 in G1 and 11/50 in G2, respectively (P=0.04). Serum albumin level after one year was 3.4 gm% in G1 and 3.6 gm in G2 (P=0.03). There was no statistically significant difference regarding the incidence of DM preoperatively and one year postoperatively.ConclusionInvagination PJ is easier to perform than duct to mucosa especially in small pancreatic duct. The soft friable pancreatic tissue can be problematic for invagination PJ due to parenchymal laceration. Invagination PJ was not associated with a lower rate of POPF, but it was associated with decreased severity of POPF and incidence of postoperative steatorrhea. CLINICAL TRIALS.Gov IdNCT02142517.Copyright © 2015 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.

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