[Accountability of anti-cholinergic drugs in increase of

Rev Med Interne · Feb 2021

Case Reports

[Accountability of anti-cholinergic drugs in increase of psychotic episodes: A case of tropatepine overdose].

Corrective treatments for some neurological side effects due to antipsychotic treatments can induce anticholinergic adverse effects. However, the risk of triggering or increasing psychotic symptoms induced by these drugs is unknown with only one case-report concerning the tropatepine. In addition, recommendations for the use of these drugs remain imprecise regarding the management of this type of adverse effect. ⋯ At high doses, anticholinergic treatments, including tropatepine, might increase psychotic episodes. In addition, the available epidemiological data reveal an inappropriate and excessive prescription of these drugs. Their use and risks should be better known and need an update of the available recommendations.

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- C Jaussaud, P Lebain, L Tessiot, S Dollfus, and J Madigand.
- Service de psychiatrie, CHU de Caen, centre Esquirol, 14000 Caen, France.
- Rev Med Interne. 2021 Feb 1; 42 (2): 127-130.
IntroductionCorrective treatments for some neurological side effects due to antipsychotic treatments can induce anticholinergic adverse effects. However, the risk of triggering or increasing psychotic symptoms induced by these drugs is unknown with only one case-report concerning the tropatepine. In addition, recommendations for the use of these drugs remain imprecise regarding the management of this type of adverse effect.Case ReportWe report the case of a psychotic episode in an 18-year-old patient potentially acutised after an auto-intoxication with tropatepine.ConclusionAt high doses, anticholinergic treatments, including tropatepine, might increase psychotic episodes. In addition, the available epidemiological data reveal an inappropriate and excessive prescription of these drugs. Their use and risks should be better known and need an update of the available recommendations.Copyright © 2020 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

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[Accountability of anti-cholinergic drugs in increase of psychotic episodes: A case of tropatepine overdose].

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