• Am J Emerg Med · Oct 2020

    Case Reports

    Tranexamic acid for ACE inhibitor induced angioedema - A case report.

    • Kellie Wang, Haden Geiger, and Andre McMahon.
    • Department of Pharmacy, Sarasota Memorial Hospital, 1700 S Tamiami Trail, Sarasota, FL 34239, United States of America. Electronic address: kelliemwang@gmail.com.
    • Am J Emerg Med. 2020 Oct 21.

    AbstractTranexamic acid (TXA) is an antifibrinolytic agent which inhibits conversion of plasminogen to plasmin, a key step in kallikrein activation and bradykinin formation. Tranexamic acid is used in prophylactic management of hereditary angioedema; however, evidence for TXA in angiotensin converting enzyme (ACE) inhibitor-induced angioedema (ACEI-AE) is limited. We describe a patient who presented to the emergency department with ACEI-AE who was successfully treated with TXA. This case suggests that TXA may be a beneficial treatment modality in the management of ACEI-AE and warrants further investigation.Copyright © 2020 Elsevier Inc. All rights reserved.

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