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- Francesco Landi, Riccardo Calvani, Matteo Cesari, Matteo Tosato, Anna Maria Martone, Roberto Bernabei, Graziano Onder, and Emanuele Marzetti.
- Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, L.go A. Gemelli 8, Rome 00168, Italy. Electronic address: francesco.landi@rm.unicatt.it.
- Clin Geriatr Med. 2015 Aug 1; 31 (3): 367-74.
AbstractPhysical function decreases with aging, which may result in adverse outcomes (eg, disability, loss of independence, institutionalization, death). Physical function impairment is a common trait of frailty and sarcopenia. These two conditions, albeit highly common, have not yet received a unique operational definition, which has impeded their implementation in standard practice. Here, we introduce a conceptual model in which sarcopenia is proposed as the biological substrate and the pathway whereby the consequences of physical frailty develop. This conceptualization may open new venues for the design of interventions against physical frailty and promote the translation of findings to the clinical arena. Copyright © 2015 Elsevier Inc. All rights reserved.
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