• S M Walther, K B Domino, R W Glenny, and M P Hlastala.
• Department of Anaesthesia and Intensive Care, Lasarettet, Norrköping, Sweden.
• Crit. Care Med. 1999 Jan 1; 27 (1): 37-45.

ObjectiveTo examine the influence of positive end-expiratory pressure (PEEP) and posture on the distribution of pulmonary blood flow.DesignExperimental study.SettingUniversity animal laboratory.SubjectsSeven anesthetized and mechanically-ventilated lambs.InterventionsFour conditions were studied in random order: prone or supine position, with or without 5 cm H2O PEEP.Measurements And Main ResultsThe distribution of pulmonary blood flow was assessed using fluorescent-labeled microspheres (15 microm) in small (approximately 1.7 cm3) lung regions. Pulmonary blood flow heterogeneity was evaluated using the coefficient of variation of blood flow of the lung regions. The number of regions analyzed were 1290+/-154 (SD) per animal. PEEP increased pulmonary blood flow heterogeneity in the supine position (47.0+/-7.7% to 54.1+/-7.3%, p < .01, paired Student's t-test), but not in the prone position (40.4+/-8.1% to 39.6+/-11.5). Dorsal to ventral (gravitational) flow gradients were present only in the supine position, and increased with PEEP (-7.2%/cm vs. -10.4% cm, p< .001).ConclusionsPEEP redistributes pulmonary perfusion to dependent lung regions in supine, but not in prone, anesthetized and mechanically-ventilated sheep.

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