• Breast · Apr 2019

    Metaplastic breast cancers: Genomic profiling, mutational burden and tumor-infiltrating lymphocytes.

    • Nancy Tray, Jessica Taff, Baljit Singh, James Suh, Nhu Ngo, Maryann Kwa, Andrea B Troxel, Young Kwang Chae, Razelle Kurzrock, Sandip Pravin Patel, Elad Sharon, Carsten Denkert, Jeffrey S Ross, and Sylvia Adams.
    • NYU Langone Health, Perlmutter Cancer Center, New York, NY, USA.
    • Breast. 2019 Apr 1; 44: 29-32.

    AbstractMetaplastic breast cancer (MPBC) is a rare subtype that accounts for <1% of all breast cancers. Although these are typically "triple negative," they are relatively chemotherapy-refractory compared to conventional triple negative invasive breast cancers with more aggressive features and an overall poor prognosis. MPBC is a heterogeneous group of tumors that are enriched for TP53 and PIK3CA mutations, and have been found to have high PD-L1 expression though the mechanisms underlying its immunogenicity remain unclear. We perform comprehensive genomic profiling in the largest MPBC dataset (n = 192) to date and assess for other potential biomarkers of immune response.Copyright © 2018 Elsevier Ltd. All rights reserved.

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