• Sheila Silveira Fernandes, Alessandra Bernadete Trovó de Marqui, Daniela Reis Fernandes Teles, Elisabete Aparecida Montovani Rodrigues Resende, Marco Fábio Prata Lima, Mariana Kefalas Oliveira Gomes, and Mariangela Torreglosa Ruiz Cintra.
• Graduada em Ciências Biológicas pela Universidade Federal do Triângulo Mineiro/UFTM, Uberaba, MG, Brasil.
• Rev Assoc Med Bras (1992). 2020 Oct 1; 66 (10): 1396-1401.

ObjectiveThe relationship between the clinicopathological and sociodemographics characteristics of acral melanomas diagnosed at BACKGROUND: This study aimed to investigate the frequency of VEGF gene insertion (I) / deletion (D) polymorphism (rs35569394) in patients with Polycystic Ovarian Syndrome (PCOS) and to compare with a control population to verify its association with the pathology.Methods206 women participated in this study, 103 with PCOS (group of patients) and 103 without the disease (control group). After extraction of genomic DNA from the samples, molecular analysis was performed by Polymerase Chain Reaction (PCR) and electrophoresis in polycrylamide. Descriptive analysis, univariate analysis and logistic regression model were used. Results were presented in odds ratio (OR) and 95% confidence interval (95% CI), considering the significance of p <0.05.ResultsThere were no statistical differences between patients and controls for allele frequencies (χ2 = 1.16, p = 0.56). The genotypic frequency distribution was in Hardy Weinberg equilibrium for the patients (χ2 = 2.42; p <0.05), but not for the control group (χ2 = 7.26; p <0.05). Regarding risk factors for the syndrome, a history of familial PCOS is more frequent among women with the syndrome.ConclusionsIn the present study, there is no association between VEGF gene I / D polymorphism and PCOS.

16 keywords...

hide…