• Annual review of medicine · Jan 1983

    Review

    Prostaglandins, glucose homeostasis, and diabetes mellitus.

    • R P Robertson.
    • Annu. Rev. Med. 1983 Jan 1; 34: 1-12.

    AbstractProstaglandins of the E series are implicated as regulators of glucose homeostasis because of their effects on glucose production and secretion of insulin and glucagon. PGE is postulated to play a role in the pathophysiology of insulin secretion in adult-onset (Type II) diabetes mellitus. Evidence supporting this hypothesis includes the demonstration that PGE inhibits glucose-induced acute insulin responses in normal humans. Moreover, drugs that inhibit synthesis of PGE improve abnormal insulin secretion in human subjects with Type II diabetes mellitus.

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