Autologous hemopoietic stem cell transplantation in the

J. Neurol. Sci. · Aug 2004

Review

Autologous hemopoietic stem cell transplantation in the treatment of multiple sclerosis: rationale and clinical experience.

Based on the encouraging results of transplantation in animals with experimental autoimmune encephalomyelitis (EAE), small-scale phase I/II trials of autologous hematopoietic stem cell transplantation (autoHSCT) were initiated in 1995 for the treatment of severe cases of multiple sclerosis (MS). More than 200 patients with treatment-resistant multiple sclerosis have been transplanted so far, mainly in Europe and the USA. The results of these studies appear promising in terms of impact on MRI disease parameters and, to a lesser extent, clinical stabilization or even improvement. Despite concerns raised by the morbidity and mortality noted in the initial pilot studies, a controlled, randomized, phase III trial of autoHSCT against the best currently available treatment, i.e., mitoxantrone, seems justified and is under way.

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- Athanasios Fassas and Vasilios K Kimiskidis.
- Department of Hematology and Bone Marrow Transplantation Unit, George Papanicolaou Hospital, 57010 Exokhi, Thessaloniki, Greece. hempap@otenet.gr
- J. Neurol. Sci. 2004 Aug 15; 223 (1): 53-8.
AbstractBased on the encouraging results of transplantation in animals with experimental autoimmune encephalomyelitis (EAE), small-scale phase I/II trials of autologous hematopoietic stem cell transplantation (autoHSCT) were initiated in 1995 for the treatment of severe cases of multiple sclerosis (MS). More than 200 patients with treatment-resistant multiple sclerosis have been transplanted so far, mainly in Europe and the USA. The results of these studies appear promising in terms of impact on MRI disease parameters and, to a lesser extent, clinical stabilization or even improvement. Despite concerns raised by the morbidity and mortality noted in the initial pilot studies, a controlled, randomized, phase III trial of autoHSCT against the best currently available treatment, i.e., mitoxantrone, seems justified and is under way.Copyright 2004 Elsevier B.V.

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Autologous hemopoietic stem cell transplantation in the treatment of multiple sclerosis: rationale and clinical experience.

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