• Nicole P Juffermans, Cécile Aubron, Jacques Duranteau, VlaarAlexander P JAPJLaboratory of Experimental Intensive Care and Anaesthesiology, Amsterdam University Medical Centre, Location Academic Medical Centre, Amsterdam, The Netherlands.Department of Intensive Care, Amsterdam UMC, Location AMC, Amsterdam, The, Daryl J Kor, Jennifer A Muszynski, Philip C Spinella, and Jean-Louis Vincent.
• Laboratory of Experimental Intensive Care and Anaesthesiology, Amsterdam University Medical Centre, Location Academic Medical Centre, Amsterdam, The Netherlands.
• Intensive Care Med. 2020 Dec 1; 46 (12): 245024572450-2457.

AbstractRed blood cell transfusions are a frequent intervention in critically ill patients, including in those who are receiving mechanical ventilation. Both these interventions can impact negatively on lung function with risks of transfusion-related acute lung injury (TRALI) and other forms of acute respiratory distress syndrome (ARDS). The interactions between transfusion, mechanical ventilation, TRALI and ARDS are complex and other patient-related (e.g., presence of sepsis or shock, disease severity, and hypervolemia) or blood product-related (e.g., presence of antibodies or biologically active mediators) factors also play a role. We propose several strategies targeted at these factors that may help limit the risks of associated lung injury in critically ill patients being considered for transfusion.

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