• GriesdaleDonald E GDEGDepartment of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada.Division of Critical Care Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.Cent, Mypinder S Sekhon, Michael D Wood, Danilo Cardim, BrasherPenelope M APMACentre for Clinical Epidemiology & Evaluation, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada., Victoria McCredie, Demetrious Sirounis, Denise Foster, Yulia Krasnogolova, Peter Smielewski, Damon C Scales, Philip N Ainslie, David K Menon, J Gordon Boyd, Thalia S Field, Paul Dorian, and Cerebral Oximetry to Assess Cerebral Autoregulation in Hypoxic-Ischemic Brain Injury (CONCEPT) Research Group, on behalf of the Canadian Critical Care Trials Group.
• Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada.
• Crit Care Explor. 2020 Oct 1; 2 (10): e0217.

AbstractWe provide preliminary multicenter data to suggest that recruitment and collection of physiologic data necessary to quantify cerebral autoregulation and individualized blood pressure targets are feasible in postcardiac arrest patients. We evaluated the feasibility of a multicenter protocol to enroll patients across centers, as well as collect continuous recording (≥ 80% of monitoring time) of regional cerebral oxygenation and mean arterial pressure, which is required to quantify cerebral autoregulation, using the cerebral oximetry index, and individualized optimal mean arterial pressure thresholds. Additionally, we conducted an exploratory analysis to assess if an increased percentage of monitoring time where mean arterial pressure was greater than or equal to 5 mm Hg below optimal mean arterial pressure, percentage of monitoring time with dysfunctional cerebral autoregulation (i.e., cerebral oximetry index ≥ 0.3), and time to return of spontaneous circulation were associated with an unfavorable neurologic outcome (i.e., 6-mo Cerebral Performance Category score ≥ 3).Copyright © 2020 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.

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