• Jamie Beverstock, Thomas Park, R Peter Alston, Celine Chan Ah Song, Amy Claxton, Thomas Sharkey, Sarah Hutton, Joseph Fathers, and Will Cawley.
• College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, United Kingdom.
• J. Cardiothorac. Vasc. Anesth. 2021 Apr 1; 35 (4): 1096-1105.

ObjectiveThe primary objective of this study was to compare one-year mortality in patients undergoing cardiac surgery with volatile anesthesia or total intravenous anesthesia (TIVA). Secondary objectives were to compare in-hospital and 30-day mortality, postoperative levels of creatine kinase (CK-MB) and cardiac troponin, and durations of tracheal intubation, intensive care unit (ICU) and hospital stays.DesignSystematic review and meta-analysis of randomized controlled trials (RCTs).SettingInternational, multi-institution centers.ParticipantsAdults patients undergoing heart surgery.InterventionsVolatile anesthesia and TIVA.Measurements And Main ResultsMeta-analysis found no statistically significant difference between patients receiving TIVA and volatile anesthesia in one-year mortality (n = 6440, OR = 1.22, 95% CI 0.97 to 1.54, p = 0.09, Z = 1.67, I2 = 0%), troponin (n = 3127, SMD = 0.26, 95% CI -0.01 to 0.52, p = 0.05, Z = 1.92, I2 = 90%) and CK-MB concentration 24h postoperatively (n = 1214, SMD = 0.10, 95% CI -0.17 to 0.36, unadjusted p = 0.48, Z = 0.71, I2 = 79%), or time to tracheal extubation (n = 1059, SMD = 0.10, 95% CI -0.28 to 0.49, p = 0.60, Z = 0.53, I2 = 88%). The durations of ICU stay (n = 2003, SMD = 0.29, 95% CI 0.01 to 0.57, p = 0.04, Z = 2.05, I2 = 88%) and hospital stay (n = 1214, SMD = 0.42, 95% CI 0.10 to 0.75, p = 0.01, Z = 2.53, I2 = 91%) were shorter in the volatile anesthetic compared to TIVA group.ConclusionsNo significant differences in mortality (in-hospital, 30-day, 1-year), troponin and CK-MB concentrations 24 h postoperatively, or time to tracheal extubation were found between patients who had volatile anesthesia or TIVA. Compared to TIVA, volatile anesthesia was associated with shorter durations of hospital and ICU stays.Copyright © 2020 Elsevier Inc. All rights reserved.

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