• H A Sitsapesan, P Holland, Z Oliphant, N De Pennington, J-S Brittain, N Jenkinson, C Joint, T Z Aziz, and A L Green.
• Oxford Functional Neurosurgery and Experimental Neurology, Oxford University, Oxford, Oxfordshire, UK Nuffield Department of Surgical Sciences, Oxford University, Oxford, Oxfordshire, UK.
• J. Neurol. Neurosurg. Psychiatr.. 2014 Jul 1;85(7):811-5.

ObjectivesTo evaluate the efficacy of deep brain stimulation (DBS) in the treatment of tremor resulting from acquired brain injury (ABI).MethodsA series of eight consecutive patients with post-ABI tremor were treated with DBS of the ventro-oralis posterior (VOP)/zona incerta (ZI) region, and subsequently underwent blinded assessments using Bain's tremor severity scale.ResultsVOP/ZI DBS produced a mean reduction in tremor severity of 80.75% based on Bain's tremor severity scale, with significant reductions in all five component tremor subscores: rest, postural, kinetic, proximal and distal. No adverse neurological complications were reported, although one patient experienced exacerbation of pre-existing gait ataxia.ConclusionVOP/ZI stimulation is demonstrated here to be an effective and safe approach for the treatment of post-ABI tremor in the largest series published at the time of writing.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

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