• Marcia Pradella-Hallinan, José Carlos Pereira, and João Roberto Maciel Martins.
• Departamento de Psicobiologia, Universidade Federal de Sao Paulo (UNIFESP), SP, BR e Hospital Sirio-Libanes, Sao Paulo, SP, BR.
• Clinics (Sao Paulo). 2020 Jan 1; 75: e2140.

ObjectivesRestless legs syndrome (RLS) is a frequent comorbid condition associated with distinct unrelated diseases. While the incidence of RLS has not been definitively confirmed, RLS-like symptoms have been reported in a section of Asian population who also had hyperthyroidism. The prevalence of RLS is generally low in Asian populations. Under these circumstances, we hypothesized that in a population where RLS is common, such as in Brazil, RLS could manifest as a comorbid ailment alongside Graves' disease, a common hyperthyroid condition.MethodsIn a cross-sectional survey, 108 patients who presented with Graves' disease were analyzed for restless legs or associated symptoms.ResultsTwelve patients (11.1%) displayed symptoms of RLS prior to the incidence of Graves' disease. These patients experienced worsening of the symptoms during their hyperthyroid state. Six patients (5.6%) developed RLS, consequent upon the incidence of Graves' disease as per the consensus of the panel of the experts. Fifteen patients (13.9%) also presented with RLS-like symptoms without any discernible circadian feature of the syndrome.ConclusionOur findings confirm that Graves' disease might trigger restless legs-like symptoms, while the condition of hyperthyroidism could also be complicated by definite RLS.

21 keywords...

hide…