• J. Exp. Med. · Jun 2020

    Targeting potential drivers of COVID-19: Neutrophil extracellular traps.

    • Betsy J Barnes, Jose M Adrover, Amelia Baxter-Stoltzfus, Alain Borczuk, Jonathan Cools-Lartigue, James M Crawford, Juliane Daßler-Plenker, Philippe Guerci, Caroline Huynh, Jason S Knight, Massimo Loda, Mark R Looney, Florencia McAllister, Roni Rayes, Stephane Renaud, Simon Rousseau, Steven Salvatore, Robert E Schwartz, Jonathan D Spicer, Christian C Yost, Andrew Weber, Yu Zuo, and Mikala Egeblad.
    • Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, The Feinstein Institutes for Medical Research & Departments of Molecular Medicine and Pediatrics, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY.
    • J. Exp. Med. 2020 Jun 1; 217 (6).

    AbstractCoronavirus disease 2019 (COVID-19) is a novel, viral-induced respiratory disease that in ∼10-15% of patients progresses to acute respiratory distress syndrome (ARDS) triggered by a cytokine storm. In this Perspective, autopsy results and literature are presented supporting the hypothesis that a little known yet powerful function of neutrophils-the ability to form neutrophil extracellular traps (NETs)-may contribute to organ damage and mortality in COVID-19. We show lung infiltration of neutrophils in an autopsy specimen from a patient who succumbed to COVID-19. We discuss prior reports linking aberrant NET formation to pulmonary diseases, thrombosis, mucous secretions in the airways, and cytokine production. If our hypothesis is correct, targeting NETs directly and/or indirectly with existing drugs may reduce the clinical severity of COVID-19.© 2020 Barnes et al.

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