• Hong Lu, Yi-Tong Huang, He-Jiang Chen, and Pei-Feng Chen.
• Department of Respiratory, Zhuji Affiliated Hospital of Shaoxing University, Zhuji, Zhejiang, P.R. China.
• Medicine (Baltimore). 2020 Nov 20; 99 (47): e21856.

BackgroundTo systematically evaluate the efficacy and safety of combined aclidinium bromide and formoterol fumarate for chronic obstructive pulmonary disease (COPD).MethodsElectronic databases including PubMed, MEDLINE, EMBASE, Cochrane Library Central Register of Controlled Trials, WanFang, and China National Knowledge Infrastructure (CNKI) database were searched for studies on the use of combined aclidinium bromide and formoterol fumarate in the treatment of COPD. Two independent researchers performed literature screening, data extraction, and assessment of quality of studies. The strength of the association of the efficacy and safety of combined aclidinium bromide and formoterol fumarate in the treatment of COPD was evaluated according to the odds ratio (OR), mean differences (MDs), and 95% confidence interval (CI). Statistical analysis was carried out via using RevMan 5.3 software.ResultsThe results of the present study will be published in a peer-reviewed journal.ConclusionThe conclusion of the present study will provide evidence to judge whether combined aclidinium bromide and formoterol fumarate is an effective and safety intervention in the treatment of COPD.Systematic Review Registration NumberINPLASY202070063.

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