• Hengchang Hu, Yuanhong Lei, Liping Yin, and Xiaoqiong Luo.
• Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province.
• Medicine (Baltimore). 2020 Nov 20; 99 (47): e22735e22735.

IntroductionHyperglycemia is closely associated with the occurrence of diabetic complications, especially for patients with type 2 diabetes mellitus. Clinical trials indicated that walking exercise could improve glycemic control in patients with type 2 diabetes mellitus, but it is difficult to draw definitive and reliable conclusions due to the small sample size and possible exaggerated efficacy of various individual clinical trials. Therefore, we will conduct systematic review and meta-analysis to assess the current evidence for the efficacy of walking on glycemic control.Methods And AnalysisThe databases of PubMed, EMBASE, Web of Science and Cochrane Library will be searched for this review. Cochrane risk-of-bias assessment tool will be applied to assess the risk of bias of included studies. A meta-analysis will be performed according to the Cochrane Handbook for Systematic Reviews of Interventions by using RevMan 5.3 and STATA/SE 14.0 software. Subgroup analysis will be conducted to investigate the sources of heterogeneity. Sensitivity analysis will be performed to assess the reliability and stability of the meta-analysis. Publication bias and small-study effects will be evaluated by a funnel plot and Eggers test if there are at least 10 studies. Additionally, the quality of evidence for this review will be assessed by Grades of Recommendations Assessment, Development and Evaluation (GRADE).ResultsThis systematic review and meta-analysis will be to assess the efficacy of walking exercise on glycemic control.ConclusionWe will provide strong evidence to determine whether walking can improve glycemic control in patients with type 2 diabetes mellitus. This study is supposed to provide references for clinical trials and patients with type 2 diabetes mellitus.Ethics And DisseminationThis study does not require ethical approval. The results of this review will be published in a peer reviewed journal.Inplasy Registration NumberINPLASY202090046.

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