• Ting Yu, ShiFan Yan, ZhenHai Chi, DaoCheng Zhu, Pan Cheng, HaiYan Li, SiYu Qin, GenPing Zhong, XiLin Ouyang, RiXin Chen, and Lin Jiao.
• Jiangxi University of Traditional Chinese Medicine.
• Medicine (Baltimore). 2020 Nov 20; 99 (47): e22943.

IntroductionThere are many injection methods for the treatment of knee osteoarthritis, but there is no comprehensive comparison, based on the fixed effect model.MethodsAccording to the retrieval strategy, we searched randomized controlled trials (RCTs) randomly from PubMed, the Cochrane Library, Embase, the China National Knowledge Infrastructure (CNKI), Wanfang Database from their inceptions to August 2020, and 2 members of us selected literatures and extracted data independently. Methodological quality was assessed by using the Cochrane bias risk tool, and meta-analysis was performed by using the Stat.14.0.ResultsThis study will evaluate the effectiveness and safety of different injectable drugs for the treatment of knee osteoarthritis and rank the efficacies of drugs, then to determine the optimal treatment.ConclusionThis study will provide evidence for the choice of injection therapy for knee osteoarthritis.Inplasy Registration NumberINPLASY202080099.

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