• Chun Zhong, Xiaoming Cheng, Bo Jia, PeiYu Xiong, Jinhua Lu, Peixu Zhang, Xinglong Liu, and Yunhui Chen.
• School of Basic Medical Science, Chengdu University of Traditional Chinese Medicine, Chengdu.
• Medicine (Baltimore). 2020 Nov 20; 99 (47): e23038.

BackgroudUlcerative colitis (UC) is a chronic inflammatory disease that involves the rectum, colon and ileum. Gancao Xiexin decoction (GCXXD) is a classic herbal formula in Shanghanlun. More and more research evidence shows that GCXXD has a certain therapeutic effect on UC. Therefore, we designed this study protocol aim to evaluate the efficacy and safety of GCXXD combine with mesalazine for UC.MethodsWe will systematically search 6 databases, including PubMed, the Cochrane Library, EMBASE, CNKI, VIP, Wang-fang database up to July 2020 to obtain eligible studies. The primary outcomes will focus on the clinical effectiveness. Review Manager 5.3 software will be used for data analysis.ResultsThis study will provide the systematic evidence of UC treated with GCXXD combine with mesalazine.ConclusionThe findings of this meta-analysis will provide evidence to judge whether GCXXD combine with mesalazine is a more effective intervention compare to mesalazine only for patient of UC.Inplasy Registration NumberINPLASY202080008.

25 keywords...

hide…