• Guan-Jun Feng, Feng Gao, Xiao-Yuan Huang, Paer Hati, Xiao-Peng Yang, and Hong-Xing Wu.
• Department of Neurosurgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China.
• Medicine (Baltimore). 2020 Nov 20; 99 (47): e23235.

BackgroundCarotid-ophthalmic aneurysms are relatively rare, and represent 1% of all intracranial aneurysms. Generally, endovascular coiling and surgical clipping are the 2 most commonly used methods to treat ruptured carotid-ophthalmic aneurysms, it provides the most favorable outcome for a patient. This study aims to assess the efficiency and safety of endovascular coiling vs surgical clipping for patients with a ruptured carotid-ophthalmic aneurysm.MethodsA comprehensive systematic literature review was done in PubMed, EMBASE, Cochrane Library, Web of Science, Scopus, China National Knowledge Infrastructure (CNKI), and WanFang databases. Only randomized trials that compared endovascular coiling with surgical clipping in patients with ruptured carotid-ophthalmic aneurysm was included. Data was extracted independently by 2 review authors. Moreover, the quality of study and bias risk was evaluated by utilizing an appropriate method. Triallists will be contacted to acquire missing information. The data is presented as risk ratio and mean difference, or standardized mean difference with 95% confidence intervals.ResultsThe results from the present research shall be published in a peer-reviewed journal.ConclusionThe present study summarizes the direct and in-direct evidence to judge the efficiency and safety of these 2 methodologies to treat ruptured carotid-ophthalmic aneurysms and attempt to find the most efficiency and safety therapeutical method.Ethics And DisseminationThe present study is a meta-analysis based on published evidence. As a result, ethics approval and patient consent are not needed.

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