• Jiao Liang, Hui Xie, Han-Jen Chiang, Sha Li, Zhiqing Liu, Jiongke Li, and Chenyi Zeng.
• Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu, Sichuan Province, PR China.
• Medicine (Baltimore). 2020 Nov 20; 99 (47): e23241.

BackgroundSudden hearing loss is an emergency health problem in the Department of Otolaryngology that must be treated in a timely manner, or may cause lifelong regrets. The application of postauricular injection of glucocorticoid is a popular treatment to recover patients hearing level in recent years. However, the effectiveness and safety of postauricular injection of glucocorticoid needs to be assessed systematically.Methods And AnalysisThe purpose of the study is to undertake a systematic review and meta-analysis on the effectiveness and safety of postauricular injection of glucocorticoid to treat patient diagnosed with sudden hearing loss. We will search the following databases from the date of publication to July 1, 2020: PubMed, EMBASE, Web of Science, the Cochrane Library, CNKI, Wanfang databases, the Chinese Biomedical Literature Database (CBM), the Chinese Science and Technology Periodical Database (VIP) and the Chinese Cochrane Centre's Clinical Trial Registry Platform. Observational studies regarding the association between postauricular injection of glucocorticoid and sudden hearing loss were written in English and Chinese were included. RevManV.5.3 software will be used for meta-analysis. According to the heterogeneity of the research results, fixed effects model, random effects model, subgroup analysis, sensitivity analysis, and others will be used. Ethics approval was not required for this protocol. The findings will be disseminated through journal articles and conference presentations.ResultsObjectively, evaluate the efficacy and safety of postauricular injection of glucocorticoid for sudden hearing loss.ConclusionTo provide evidence-based medicine for glucocorticoid treatment methods in patients with sudden hearing loss.Osf Registration NumberDOI 10.17605/OSF.IO/N5RV3.

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