• Mazda K Turel, Sumit Thakar, and Vedantam Rajshekhar.
• Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.
• J. Neurosurg.. 2015 Feb 1;122(2):303-11.

ObjectProspective studies of quality of life (QOL) are infrequently performed in patients undergoing surgery for vestibular schwannoma (VS). The authors designed this to study to investigate health-related QOL (HR-QOL) in patients with large and giant VSs before and after surgery.MethodsBetween January 2009 and December 2012, HR-QOL was measured prospectively before and after surgery, using the 36-Item Short Form Health Survey (SF-36), in 100 patients who underwent surgery for unilateral large or giant VS (tumor size≥3 cm). The Glasgow Benefit Inventory (GBI) was also used to evaluate the effect of surgery.ResultsA total of 100 patients were included in the study (65 men and 35 women). Their mean age (±SD) was 44.2±11.5 years. The preoperative QOL was decreased in all SF-36 domains. A 1-year follow-up evaluation was conducted for all patients (mean 13.5±5.3 months after surgery). The results showed an improvement in HR-QOL compared with preoperative status in all cases, with 63%-85% of patients showing a minimum clinically important difference (MCID) in various domains. A second follow-up evaluation was performed in 51 cases (mean time after surgery, 29.0±8.3 months) and showed sustained improvement in SF-36 scores. In some domains there was further improvement beyond the first follow-up. On the GBI, 87% of patients reported improvement, 1% felt no change, and 12% of patients reported deterioration.ConclusionsPatients harboring large or giant VSs score lower on all the QOL domains compared with the normative population. More than 60% showed a clinically significant improvement in HR-QOL 1 year after surgery, a result that was sustained at subsequent follow-up.

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