• Nie Zhang, Ruiyuan Yun, Lin Liu, and Liu Yang.
• Department of Endocrinology, Jingjiang People's Hospital, the Seventh Affiliated Hospital of Yangzhou University, Jiangsu, China.
• Medicine (Baltimore). 2020 Nov 20; 99 (47): e23392e23392.

BackgroundThe impact of glycosylated hemoglobin on mortality in patients with coronavirus disease 2019 (COVID-19) and type 2 diabetes (T2D) remains uncertain. In this study, we aim to assess the effect of pre-hospital blood glucose regulation on patients with COVID-19 and pre-existing T2D.MethodsAll randomized controlled trials (RCTs) and cohort studies of association of glycosylated hemoglobin and outcomes in patients with COVID-19 and T2D will be included in this review. PubMed, Embase, and CNKI will be searched for relevant literature, up to August 20, 2020 in English and Chinese language. Two reviewers will select trials independently for inclusion and assess trial quality. Two pairs of authors will independently extract information for each included trials. Primary outcomes are death and composite adverse outcomes: the number of participants who died or remained severely disabled. Revman 5.3 will be used for heterogeneity assessment, data synthesis, subgroup analysis, sensitivity analysisa and generating funnel-plots.ResultsWe will provide practical results about the association of glycosylated hemoglobin and outcomes in patients with COVID-19 and T2D.ConclusionThe stronger evidence about the association of glycosylated hemoglobin and outcomes in patients with COVID-19 and T2D will be provided for clinical practice.Systematic Review RegistrationPROSPERO CRD42020200574.Ethics And DisseminationThere is no need for ethical approval, and the review will be reported in a peer-reviewed journal.

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