• Ahmad N Alzubaidi, Ibrahim Karabayir, Oguz Akbilgic, and Max R Langham.
• Department of Urology, University of Tennessee Health Science Center, Memphis, Tennessee.
• Ann. Surg. 2022 Jun 1; 275 (6): 119411991194-1199.

ObjectiveTo understand the temporal relationships of postoperative complications in children and determine if they are related to each other in a predictable manner.Summary Of Background DataChildren with multiple postoperative complications have increased suffering and higher risk for mortality. Rigorous analysis of the temporal relations between complications, how complications might cluster, and the implications of such clusters for children have not been published. Herein, we analyze the relationships between postoperative complications in children.MethodsData source: Surgical operations included in the National Surgical Quality Improvement Program Pediatric Participant Use Data File from 2013 to 2017. The main outcomes measure was presence of 1 or more postoperative complications within 30 days of surgery. Operations followed by multiple complications were analyzed using network analysis to study prevalence, timing, and co-occurrences of clusters of complications.ResultsThis study cohort consisted of 432,090 operations; 388,738 (89.97%) had no postoperative complications identified, 36,105 (8.35%) operations resulted in 1 postoperative complication and 7247 (1.68%) operations resulted in 2 or more complications. Patients with multiple complications were more likely to be younger, male, African American, with a higher American Society of Anesthesiologists score, and to undergo nonelective operations (P < 0.001). More patients died with 2 complication versus 1 complication vs no complication (5.3% vs 1.5% vs 0.14%, P < 0.001). Network analysis identified 4 Louvain clusters of complications with dense intracluster relationships.ConclusionsChildren with multiple postoperative complications are at higher risk of death, than patients with no complication, or a single complication. Multiple complications are grouped into defined clusters and are not independent.Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.

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