• Egle Jezerskyte, Alexander C Mertens, DierenSusan vanSVAmsterdam UMC, location AMC, University of Amsterdam, Department of Surgery, Cancer Center Amsterdam, Amsterdam, The Netherlands., Wietse J Eshuis, SprangersMirjam A GMAGDepartment of Medical Psychology, Amsterdam UMC, location AMC, University of Amsterdam, The Netherlands., Mark I van Berge Henegouwen, Suzanne S Gisbertz, and Dutch Upper Gastrointestinal Cancer Audit (DUCA) group.
• Amsterdam UMC, location AMC, University of Amsterdam, Department of Surgery, Cancer Center Amsterdam, Amsterdam, The Netherlands.
• Ann. Surg. 2022 Dec 1; 276 (6): e735e743e735-e743.

ObjectiveInvestigate long-term survival, morbidity, mortality, and pathology results in patients following esophagectomy or total gastrectomy for gastroesophageal junction (GEJ) cancer.BackgroundBoth a total gastrectomy and an esophagectomy may be valid treatment options in patients with GEJ cancer. Which procedure results in the most optimal patient outcome is not well studied. The aim of this study was to investigate the long-term survival, morbidity, mortality, and pathology results in patients following esophagectomy or total gastrectomy for GEJ cancer.MethodsA retrospective comparative cohort study of prospectively collected data from the Dutch Upper GI Cancer Audit combined with survival data of the Dutch medical insurance database was performed. Patients with GEJ cancer in whom a total gastrectomy or an esophagectomy was performed between 2011 and 2016 were compared. The primary outcome was 3-year overall survival. Postoperative morbidity, mortality, 3-year conditional survival, radicality of resection, and lymph node yield were secondary endpoints.ResultsA total of 871 patients were included: 790 following esophagectomy and 81 following gastrectomy. The 3-year overall survival was 35.8% after esophagectomy and 28.4% after gastrectomy (hazard ratio 1.2, 95% confidence interval 0.721-1.836, P = 0.557). Postoperative morbidity, mortality, radicality of resection, lymph node yield, and 3-year conditional survival did not differ significantly between groups.ConclusionA total gastrectomy and an esophagectomy for GEJ cancer show largely comparable results with regard to long-term survival, postoperative morbidity, mortality, and pathology results. If both procedures are feasible, other parameters such as surgeon's experience and quality of life should be considered when planning for surgery.Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc.

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