• Der Anaesthesist · Oct 2011

    [Silexan and narcosis : case report and possibilities of preoperative and perioperative management].

    • S O Decker and H Polarz.
    • Klinik für Anästhesiologie, Universitätsklinikum Heidelberg, Deutschland. sebastian.decker@med.uni-heidelberg.de
    • Anaesthesist. 2011 Oct 1; 60 (10): 946-9.

    AbstractThe increased use of phytotherapeutic drugs means that anesthetists are more often confronted with these drugs. In this case report possible problems which can occur are demonstrated exemplified by silexan. Silexan is a phytotherapeutic anxiolytic which is used in anxiety disorders. Because of its potential mechanism of action via the neurotransmitter gamma-aminobutyric acid (GABA) receptors interactions with narcotic drugs are possible. The case of an 18-year-old girl who underwent an operation under general anesthesia while taking silexan as long-term medication is presented. The desired depth of narcosis could only be reached by inhalative induction with sevoflurane after unsuccessful induction attempts using intravenous propofol and thiopental. Possible explanations for this route and inhalative induction as a possible alternative are discussed.

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