• Søren Mose Hansen, Ulrik Sprogøe, Sören Möller, and Claus Andersen.
• Department of Anesthesiology and Intensive care, Odense University Hospital, Odense, Denmark.
• Acta Anaesthesiol Scand. 2021 Apr 1; 65 (4): 466472466-472.

BackgroundIncreased bleeding and blood product transfusions during cardiac surgery are associated with poor outcomes. The patient's ABO blood group is related to hemostatic balance, although it is unclear whether this influences bleeding during cardiac surgery. This study aimed to evaluate whether ABO blood group is related to bleeding during cardiac surgery.MethodsThis retrospective study evaluated data from 17,058 cardiac surgical procedures that were performed in four Danish cardiosurgical centers. Data regarding chest tube drainage and transfusion volumes were retrieved from a clinical database and combined with information regarding ABO group. The primary outcome was chest tube drainage volume and the secondary outcomes were transfused volumes of various blood products.ResultsBlood group O had the largest chest tube drainage volume (mean: 745 mL, 95% CI: 720-771 mL) and blood group AB had the smallest volume (mean: 664 mL, 95% CI: 598-731 mL). The inter-group difference in the mean drainage volume was 81 mL (95% CI: 8-154 mL, P < .05). Patients with blood group A or blood group B had mean drainage volumes that were between the volumes for groups AB and O. Relative to group O, group AB received smaller mean volumes of all blood products. The most pronounced difference was in platelet concentrates, with mean values of 170 mL for group O (95% CI: 157-184 mL) and 63 mL for group AB (95% CI: 34-92 mL).ConclusionThe patient's ABO group appears to be related to volumes of chest tube drainage and transfused blood products during cardiac surgery.© 2020 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

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