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- C Habelt, F Kessler, C Distler, M Kress, and P W Reeh.
- Institute of Physiology and Experimental Pathophysiology, Erlangen, Germany.
- Neuroreport. 2000 Apr 7; 11 (5): 973-6.
AbstractThe rat skin-saphenous nerve preparation was used to record from mechano-heat sensitive C-fibers whose receptive fields were superfused with various solutions of low pH and of bradykinin, serotonin and prostaglandin E2. Only synchronous application of protons and mediators resulted in a significant nearly three-fold augmentation of the nociceptive pH response, and capsazepine (10(-5) M) did not block this short-lived enhancement. Thus, it does not seem to involve the capsaicin receptor (VRI) which is in contrast to a previous finding from cultured sensory neurons.
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