• Filip Rangatchew, Peter Vester-Glowinski, Bo Sonnich Rasmussen, Eva Haastrup, Lea Munthe-Fog, Maj-Lis Talman, Christian Bonde, Krzysztof T Drzewiecki, Anne Fischer-Nielsen, and Rikke Holmgaard.
• Department of Plastic Surgery and Burn Treatment, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. Electronic address: filip.rangatchew@hotmail.com.
• Burns. 2021 Mar 1; 47 (2): 270-294.

AimMesenchymal stem cell (MSC) therapies are emerging as a promising strategy to promote tissue repair, and may extend their utility to burn care. This comprehensive review of the extant literature, evaluated all in vivo studies, to elucidate the potential protective and therapeutic effect of MSCs in acute thermal skin burns.MethodsPubMed was systematically searched, according to PRISMA guidelines, and all relevant preclinical and clinical studies were included according to pre-specified eligibility criteria.ResultsForty-two studies were included in a qualitative synthesis, of which three were human and 39 were animal studies. The preclinical studies showed that MSCs can significantly reduce inflammation, burn wound progression and accelerate healing rate of acute burns. The underlying mechanisms are complex and not fully understood but paracrine modulators, such as immunomodulatory, antioxidative and trophic factors, seem to play important roles. Allogeneic MSC therapy has proved feasible in humans, and could allow for prompt treatment of acute burns in a clinical setting.ConclusionMSC therapy show positive results, regarding improved burn wound healing and immunologic response. However, most findings are based on small animal studies. Randomized clinical trials are warranted to investigate the regenerative effects in human burns before translating the findings into clinical practice.Copyright © 2020 Elsevier Ltd and ISBI. All rights reserved.

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