• Chuqiao Sheng, Chunfeng Yang, Zhe Jing, and Yumei Li.
• Department of Pediatric Intensive Care Unit, First Hospital of Jilin University, Jilin, China.
• J. Cardiothorac. Vasc. Anesth. 2021 Nov 1; 35 (11): 3307-3310.

BackgroundMalignant hyperthermia (MH) is a rare and potentially life-threatening pharmacogenetic disorder encountered during general anesthesia, with the incidence higher in children than in adults. Dantrolene is the specific antagonist of MH, but it is not readily available in China, thus developing alternative treatment protocols is of great practical importance.Case PresentationHerein, the authors report a two-month-old infant who underwent holmium laser epiglottis retrofitting through a bronchoscope, but developed limb muscular stiffness, tachypnea, tachycardia, and hyperthermia after sevoflurane exposure. After the diagnosis of MH, corresponding supportive treatment was implemented. Because there was no dantrolene available, continuous blood purification and mechanical ventilation were performed. A few days later, the boy recovered without any complications.ConclusionBased on the authors' successful clinical practice, the authors consider continuous blood purification as a reliable treatment for MH. But its feasibility still needs to be clarified after multicenter clinical observations.Copyright © 2020 Elsevier Inc. All rights reserved.

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