• Rev Med Interne · May 2021

    Case Reports

    [Gamma heavy chain disease associated with aggressive B lymphoma in the context of myelodysplastic syndrome].

    • C Nivet, L Deluche, and M Carreiro.
    • Centre hospitalier Montauban, 84, avenue 11(e) Régiment Infanterie, 82000 Montauban, France. Electronic address: nivetcaroline5@gmail.com.
    • Rev Med Interne. 2021 May 1; 42 (5): 355-358.

    IntroductionHeavy chain disease is a rare entity characterized by the production of incomplete immunoglobulin heavy chain without associated light chain. It is a B-cell lymphoproliferation, categorized according to the immunoglobulin involved. It is often associated with lymphomas but also with autoimmune diseases.ObservationWe report the case of a 70-year-old patient who presented a gamma-type heavy chain disease, associated with a diffuse large B-cell lymphoma in the context of myelodysplastic syndrome.ConclusionThis is the first case of diffuse large B-cell lymphoma associated gamma heavy chain disease described in the context of myelodysplastic syndrome.Copyright © 2020 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

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