• Aaron P Mitchell, Niti U Trivedi, Renee L Gennarelli, Susan Chimonas, Sara M Tabatabai, Johanna Goldberg, Luis A Diaz, and Deborah Korenstein.
• Memorial Sloan Kettering Cancer Center, New York, New York (A.P.M., N.U.T., R.L.G., S.C., S.M.T., L.A.D., D.K.).
• Ann. Intern. Med. 2021 Mar 1; 174 (3): 353361353-361.

BackgroundFinancial payments from the drug industry to U.S. physicians are common. Payments may influence physicians' clinical decision making and drug prescribing.PurposeTo evaluate whether receipt of payments from the drug industry is associated with physician prescribing practices.Data SourcesMEDLINE (Ovid), Embase, the Cochrane Library, Web of Science, and EconLit were searched without language restrictions. The search had no limiting start date and concluded on 16 September 2020.Study SelectionStudies that estimated the association between receipt of industry payments (exposure) and prescribing (outcome).Data ExtractionPairs of reviewers extracted the primary analysis or analyses from each study and evaluated risk of bias (ROB).Data SynthesisThirty-six studies comprising 101 analyses were included. Most studies (n = 30) identified a positive association between payments and prescribing in all analyses; the remainder (n = 6) had a mix of positive and null findings. No study had only null findings. Of 101 individual analyses, 89 identified a positive association. Payments were associated with increased prescribing of the paying company's drug, increased prescribing costs, and increased prescribing of branded drugs. Nine studies assessed and found evidence of a temporal association; 25 assessed and found evidence of a dose-response relationship.LimitationThe design was observational, 21 of 36 studies had serious ROB, and publication bias was possible.ConclusionThe association between industry payments and physician prescribing was consistent across all studies that have evaluated this association. Findings regarding a temporal association and dose-response suggest a causal relationship.Primary Funding SourceNational Cancer Institute.

9 keywords...

hide…