• Çağrı Bilgiç, Şiran Keske, Erman Sobutay, Uğur Can, Serkan Zenger, Bülent Gürbüz, Önder Ergönül, and Orhan Bilge.
• American Hospital, General Surgery, Istanbul, Turkey.
• Int. J. Infect. Dis. 2020 Jun 1; 95: 148-152.

BackgroundThe rate of surgical site infection (SSI) after pancreaticoduodenectomy (PD) is high and insertion of preoperative bile duct catheterization (PBDC) predispose a high risk of SSI with multidrug resistant (MDR) microorganisms.AimTo describe the effects of PBDC and the prophylaxis in development of SSI.MethodsWe conducted a retrospective study between January 01, 2010 and December 2018 including the patients with PD and total pancreatectomy.FindingsIn total 214 consecutive patients were included. The PBDC was inserted to 63 (29%) patients. The rate of intraoperative bile fluid culture positivity was higher among the patients with PBDC (84% vs. 17% respectively, p<0.001). The SSI was detected in 52 patients (24%). In multivariate analysis, the rate of SSI was found to be higher among the patients with PBDC (OR: 2.33, 95% Cl: 1.14-4.76, p=0.02). As the etiologic agents of SSI, Pseudomonas spp. and MDR pathogens were mainly detected in PBDC group. The resistance to ampicillin-sulbactam was significantly higher in the PBDC group (87.5% vs. 25%, p=0.012). The similar bacterial species both in bile fluid and the surgical site were detected in 11 (21%) patients with SSI. Among 8 patients (15%), antimicrobial susceptibility was the same. Only in five out of 52 (10%) patients, the SSI pathogens was susceptible to the agent that was used for surgical prophylaxis.ConclusionUnnecessary catheterizations should be avoided. By considering the increasing prevalence of resistant bacteria as the cause of SSI, the clinicians should closely follow-up their patients for choosing the proper antimicrobials.Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

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