• C Brotons, D Ariño, I Borrás, F Buitrago, M L González, P Kloppe, D Orozco, J M Pepió, P Rodríguez, A I Rodríguez, and Equipo Investigador del Estudio PREseAP.
• Unidad de Investigación, EAP Sardenya, Equip d'Atenció Primària Sardenya, Barcelona, Spain. cbrotons@eapsardenya.net
• Aten Primaria. 2006 Mar 31; 37 (5): 295-8.

ObjectivesTo assess the efficacy of a comprehensive secondary prevention programme to reduce morbidity and mortality in patients who have suffered a cardiovascular (CV) event; to control CV risk factors and prophylactic treatment in order to prevent recurrence; and to improve the quality of life of patients with cardiovascular disease.DesignRandomised, pragmatic, open clinical trial in primary care.SettingA total of 42 primary care centres of 8 different areas in Spain.ParticipantsMen and women below 86 years old, diagnosed with coronary disease and/or stroke and/or peripheral vascular disease in the preceding year, and who have no serious or terminal disease.InterventionPrimary care centres will be randomised to following usual care (control group), or to following a comprehensive programme of secondary prevention (intervention group).Main MeasurementsCardiovascular fatal events, cardiovascular non-fatal events, total mortality and health-related quality of life (SF-36).

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