• Roberto Cilia, Emanuele Cereda, Catherine Klersy, Margherita Canesi, Anna L Zecchinelli, Claudio B Mariani, Silvana Tesei, Giorgio Sacilotto, Nicoletta Meucci, Michela Zini, Claudio Ruffmann, Ioannis U Isaias, Stefano Goldwurm, and Gianni Pezzoli.
• Parkinson Institute, Istituti Clinici di Perfezionamento, Milano, Italy.
• J. Neurol. Neurosurg. Psychiatr. 2015 Aug 1; 86 (8): 849-55.

BackgroundA very limited number of studies report data on the clinical features of Parkinson's disease (PD) 20 years after onset and beyond.ObjectiveTo characterise PD 20 years after onset, investigating the impact of age at onset and disease duration on the clinical picture and the predictors of outcomes in patients reaching the 20-year time point.MethodsWe conducted a retrospective, cross-sectional study and a longitudinal study. All case visits of patients with a disease duration ≥20 years (N=401) were stratified by disease duration (20-22, 23-25, ≥26 years) and by age at onset (cut-off, 50 years). Patients with a disease duration of 20-22 years (N=320) were prospectively followed up for a median of 45 months (IQR 23-89) for the new occurrence of fracture, percutaneous endoscopic gastrostomy, institutionalisation, confinement to a wheelchair or bed and death.ResultsOlder age at onset and longer disease duration were independently associated with a higher prevalence of major motor and non-motor milestones of disease disability (no interaction observed). In the longitudinal study, the most frequent outcomes were death (N=92), confinement to a wheelchair or bed (N=67) and fracture (N=52). Mortality was associated with the gender: male, older age, dysphagia, orthostatic hypotension, postural instability, fractures and institutionalisation. Fracture was associated with postural instability. Predictors of permanent confinement to a wheelchair or bed were older age, postural instability and institutionalisation. Comorbid dementia at the 20-year examination did not predict any of the outcomes.ConclusionsAge at onset and disease duration are independent determinants of the clinical features of PD beyond 20 years. Non-motor symptoms depend more on age at onset rather than the disease duration itself. Non-levodopa-responsive axial symptoms are the main predictors of all relevant outcomes.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

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